Group Companies

Otsuka Pharmaceutical Co., Ltd. Manufacture, sales, import/export of pharmaceuticals, clinical testing and medical equipment, food products and cosmetics Otsuka Pharmaceutical Factory, Inc. Manufacture and sale of drugs (mainly clinical nutrition products), medical devices, and functional foods Taiho Pharmaceutical Co., Ltd. Manufacture, sales, import and export of pharmaceuticals and medical devices Otsuka Warehouse Co., Ltd. Warehousing and transport business Otsuka Chemical Co., Ltd. Manufacture and sales of chemical products Otsuka Foods Co., Ltd. Manufacture, sales, and import of foods and beverages Otsuka Medical Devices Co., Ltd. R&D, manufacture, and sales of medical devices and all related operations, as well as medical device operational management for companies within the Otsuka group Otsuka Business Support Co., Ltd. Shared service business a.trax, inc. Travel agency Otsuka Electronics Co., Ltd. Manufacture and sales of analysis and measurement equipment Otsuka Wellness Vending Co., Ltd. Sales of nutritional products and beverages through vending machine Nippon Pharmaceutical Chemicals Co., Ltd. Research and development and manufacture of pharmaceutical intermediates Otsuka Mechatronics Co., Ltd. Manufacture and sales of various types of testing equipment such as vehicle headlight testers Heartful Kawauchi Co., Ltd. Office support, manufacturing support, and agriculture business Tokushima Vortis Co., Ltd. ^* Provision of soccer entertainment, soccer school, etc. Otsuka Techno Corporation Manufacture and sales of synthetic resin molded products EN Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products J.O. Pharma Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka Ridge Co., Ltd. Operation of Hotel Ridge and California Table Okayama Taiho Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Taiho Innovations, LLC Venture capital business, incubation business Otsuka Packaging Industries Co., Ltd. Manufacture and sales of paper products Otsuka Harumi-development Co.,Ltd. Rental space and rental office business Dairin Integrated Transportation Co., Ltd. ^* Warehousing and transport business HAIES Service Co., Ltd. ^* Transport business Kitasato-Otsuka Biomedical Assay Laboratories Co., Ltd. ^* Provision of clinical testing services Otsuka Ohmi Ceramics Co., Ltd. Planning, design, production and construction of large ceramic boards, ceramic board masterpiece art, ceramic walls, reliefs, terracotta, OT ceramics, ceramic portraits and ceramic sign boards Higashiyama Film Co., Ltd. Processing and marketing of functional film Otsuka-MGC Chemical Company., Inc. Manufacture and sales of chemical products SynCrest Inc. Research, development, and manufacturing of pharmaceuticals JIMRO Co., Ltd. Manufacture, sales, rental, export, import, research and development of medical devices Lilium Otsuka Co., Ltd. Research and development, manufacturing, and marketing of medical devices and related products Otsuka Digital Health Co., Ltd. Providing IT solution services Earth Corporation ^* Manufacturing, marketing, and import/export of pharmaceutical products, quasi-drugs, medical tools, household products, etc. Earth Environmental Service Co., Ltd. ^* General environmental health management Nichiban Co., Ltd. ^* Manufacturing and sales of adhesive tape for medical, stationary, industrial use

Otsuka Australia Pharmaceutical Pty Ltd. Import and sales of pharmaceutical proudcts Otsuka Beijing Research Institute Clinical development and research of pharmaceutical products Sichuan Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Zhejiang Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka (China) Investment Co., Ltd. Holding company Otsuka Shanghai Research Institute Research and development of pharmaceuticals Tianjin Otsuka Beverage Co., Ltd. Manufacture and sales of soft drinks and beverages Otsuka Sims (Guangdong) Beverage Co., Ltd. Manufacture and sales of soft drinks Pharmavite (Shanghai) Nutrition Technology Co., Ltd. Sales of nutritional products Otsuka Electronics (Suzhou) Co., Ltd. Import/exportand sales of analysis and measurement equipment Suzhou Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Nanjing Otsuka Techbond Techno Co., Ltd. Manufacture and sales of synthetic resin molded products（3-layer film and 5-layer film） Leshan Otsuka Techno Co., Ltd. Manufacture and sales of plastic molded products and packaging materials for food and pharmaceutical products Taiho Pharmaceutical of Beijing Co., Ltd. Providing information on pharmaceuticals and clinical development work Shanghai Otsuka Foods Co., Ltd. Manufacture and sales of food products Zhangjiagang Otsuka Chemical Co., Ltd. Manufacture and marketing of flaky titanate and special compounds Otsuka Chemical (Shanghai) Co., Ltd. Import/export and sales of chemical products Otsuka Material Science & Technology (Shanghai) Co., Ltd. Research and development, and assessment of high-valued-added compounds and combination agents Otsuka South China Precision Instruments (Shenzhen) Co., Ltd. Manufacture and sales of plastic precision parts China Otsuka Pharmaceutical Co., Ltd. ^* Manufacture and sales of pharmaceutical products Guangdong Otsuka Pharmaceutical Co., Ltd. ^* Manufacture and sales of pharmaceutical products MicroPort Scientific Corporation ^* Holding company Otsuka Pharmaceutical (H.K.) Ltd. Sales of pharmaceutical products and beverages Noble Skill Limited Sales of resin, resin parts and assembling parts Taiwan Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka Tech Electronics Co., Ltd. Manufacture, sales, and maintenance of analysis and measurement equipment King Car Otsuka Co., Ltd. ^* Manufacture and sales of beverages and foods Egypt Otsuka Pharmaceutical Co., S.A.E. Manufacture and sales of pharmaceutical products Otsuka Al-Obour Pharmaceutical Egypt S.A.E. Sales of IV solutions Otsuka Gypto Pharmaceutical Egypt S.A.E. ^* Sales of pharmaceutical producs including IV solutions Otsuka Pharmaceutical India Private Limited Manufacture and sales of basic infusion and clinical nutrition products Otsuka Chemical (India) Private Limited Manufacture and sales of chemical products PT Amerta Indah Otsuka Manufacture and sales of soft drinks and beverages PT Otsuka Indonesia Manufacture and sales of pharmaceutical products PT Widatra Bhakti Manufacture and sales of pharmaceutical products PT Otsuka Jaya Indah Purchasing and sales of beverages and agricultural products PT Merapi Utama Pharma Purchasing and sales of pharmaceutical products and medical equipment PT Lautan Otsuka Chemical Manufacture and sales of chemical products PT Otsuka Distribution Indonesia Conducting business in large trading in general, including trade in import and export Otsuka Pharmaceuticals (Malaysia) Sdn. Bhd. Sales of pharmaceutical products Otsuka Nutraceutical Mexico S.A. de C.V. Import and sales of beverages and food products Otsuka Myanmar Company Ltd. Marketing and distribution of nutraceutical products Diatranz Otsuka Limited Development and manufacturing of Xenotransplantation products OTSUKA NIGERIA NUTRACEUTICALS COMPANY LIMITED Manufacture, import, and sales of beverages Otsuka Pakistan Ltd. Manufacture and sales of pharmaceutical products Otsuka (Philippines) Pharmaceutical, Inc. Manufacture and sales of pharmaceutical and nutritional products OTSUKA-SOLAR Philippines Incorporated Import and sales of beverages and foods Otsuka Pharmaceuticals (Singapore) Pte. Ltd. Sales of pharmaceutical products Taiho Pharma Asia Pacific Pte. Ltd. Import and sales of pharmaceutical products Korea Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka Electronics Korea Co., Ltd. Import, manufacture and sales of analytical instruments and measuring instruments KOC Co., Ltd. Manufacture and marketing of hydrazine Dong-A Otsuka Co., Ltd. ^* Manufacture and sales of beverages and foods Otsuka Nutraceutical (Thailand) Co., Ltd. Manufacture, sales, import, and export of beverages and food products Thai Otsuka Pharmaceutical Co., Ltd. ^* Manufacture and sales of pharmaceutical products Abdi Ibrahim Otsuka Pharmaceutical Company Sales of pharmaceutical products Otsuka Thang Nutrition Co., Ltd. Sales of beverages and foods Otsuka Pharmaceutical Vietnam Joint Stock Company Manufacture and sales of clinical nutrition products Otsuka Techno Vietnam Co., Ltd. Manufacture and sales of packaging materials and electronic parts

Otsuka Canada Pharmaceutical, Inc. Sales and marketing of pharmaceutial products Mindset Pharma, Inc. Drug discovery research and development Taiho Pharma Canada, Inc. Preparation for anticancer drug sales Daiya Foods Inc. Manufacture and sales of plant-based foods Otsuka America, Inc. Holding company Otsuka America Pharmaceutical, Inc. Manufacture and sales of pharmaceutical products Otsuka Pharmaceutical Development & Commercialization, Inc. Clinical development and commercialization of pharmaceutical products Otsuka Global Insurance, Inc. Reinsurance underwriting for the Otsuka Group Pharmavite LLC Manufacture and sales of nutritional products Ridge Vineyards, Inc. Manufacture and sales of wine Cambridge Isotope Laboratories, Inc. Manufacture and sales of reagents for research, such as stable isotopes CIL Isotope Separations, LLC Production facility for the separation of isotopes Crystal Geyser Water Company Manufacture and sales of soft drinks and beverages FoodState Inc. Production and sales of natural and whole food supplements Otsuka Precision Health, Inc. Software and services to improve management of mental healthcare systems Uqora, Inc. Development and sales of the products for urinary tract health Bonafide Health, LLC Manufacture, and sales of products for women's health Taiho Oncology, Inc. Clinical development and commercialization of anticancer drugs Taiho Ventures, LLC Venture Capital Cullinan Pearl Corporation Clinical development of anticancer drugs Otsuka Chemical America, Inc. Manufacturing and selling Terracess (fiber-free potassium titanate) CG Roxane LLC ^* Manufacture and export of soft drinks and beverages Recor Medical, Inc. Research and development, manufacturing, and sales of medical devices Visterra, Inc. Research and development of phramceutical products A&P Inphatec, LLC Research and development, manufacture and sales of bio-pesticides McQuade Center for Strategic Research and Development LLC Make investment in pharmaceutical opportunities Otsuka Nutraceutical Emerging Ventures LLC Nutraceuticals venture capital

Nutrition & Sante Benelux S.A. Sales of functional and dietetic foods Interpharma Praha, a.s. Manufacture and sales of pharmaceutical and nutrition products Nardobel SAS Holding company Nutrition & Sante SAS Manufacturing and distributing of functional and dietetic foods Otsuka Pharmaceutical France SAS Purchasing and sales of pharmaceutical products ALMA S.A. ^* Holding company of Alma Group, which manufactures and markets of spring water and mineral water Otsuka Pharma GmbH Purchasing and sales of pharmaceutical products Advanced Biochemical Compounds GmbH Development and manufacturing of chemicals for nuclear medicine applications Otsuka Novel Products GmbH Research and development related to tuberculosis Otsuka Medical Devices Europe GmbH Sales of medical devices Otsuka Holdings Europe GmbH Shared service business Otsuka Pharmaceutical Italy S.r.l. Sales of pharmaceutical products Nutrition & Sante Italia SpA Sales of functional and dietetic foods Otsuka Pharmaceutical Netherlands BV Marketing Authorisation Holder for Otsuka European entities Otsuka Pharmaceutical, S.A. Manufacture and sales of pharmaceutical products Hebron S.A. Manufacture and sales of industrial chemicals Trocellen Iberica S.A. Manufacture and marketing of polyolefin foams Nutrition & Sante Iberia SL Sales of functional and dietetic foods Otsuka Pharma Scandinavia AB Purchasing and sales of pharmaceutical products Otsuka Pharmaceutical (Switzerland) GmbH Sales of pharmaceutical products Taiho Oncology Europe GmbH Development and sales of pharmaceutical products Otsuka Pharmaceutical Europe Ltd. Manufacture and sales of pharmaceutical products Otsuka Pharmaceuticals (U.K.) Ltd. Purchasing and sales of pharmaceutical products Astex Therapeutics, Ltd. Drug discovery research and development Veryan Holdings Ltd. Holding company Veryan Medical Ltd. Research and development, manufacturing, and sales of Peripheral Artery Stent